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The effects of insulin on glucose and lipid metabolism are mainly mediated by the IRTK-induced phosphorylation of IRS, which then recruits phosphatidylinositol-3-OH kinase (PI3K) and catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate (PIP2)
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The crystal structure of human FSP1 was recently solved 21,55,56,57 , revealing that the ribityl moiety of FAD is stabilized through interactions with residues D41, N49 and D285 of FSP1 (Fig
where they play a role in normal energy metabolism
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