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These models for species with up to three ionizable centers were summarized in a 2004 review article by Poole.52 The pK a may be determined by numerically fitting the resulting relations to a plot of mobility versus pH through nonlinear regression, as shown in Figure 9 for the case of 2-aminopyridine.54 The shape of these curves depends only upon m d and the position depends only upon pK a , therefore this regression directly yields the pK a value(s) of interest

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Due to the increased rise in cardiovascular mortality, those with chronic kidney disease (CKD) or end-stage renal disease (ESRD) have a significantly shorter life expectancy than people with adequate renal function [7]