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If you’re having issues with playing the video above, play this instead: This lesson provides an introduction to glutathione, including its roles in the antioxidant defense system, detoxification, and the control of protein function through controlling disulfide bond formation

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Interestingly, by inducing PC12 differentiation, we obtained a phenotype that was significantly more resistant to t BH and this resistance to oxidative damage corresponded to a highly reduced intracellular GSH redox environment and decreased expression of Apaf-1 [65], suggesting that the GSH redox status can influence differential apoptotic susceptibility in various cell phenotypes