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These probiotics exert their effects through diverse mechanisms, including the upregulation of TJ proteins (e.g., occludin, claudins, ZO-1), suppression of proinflammatory cytokines, inhibition of NF-κB, myosin light chain kinase (MLCK) and MAPK signaling pathways, and activation of host pattern recognition receptors such as TLR-2 and PPARγ
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In all cases at least one of these clusters could not be clearly defined as mushroom, thin, or study spines
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