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iNOS is activated during inflammatory responses or hypoxia and produces large amounts of NO, which can lead to oxidative stress if not properly controlled ( In the bloodstream, NO is rapidly captured by hemoglobin, forming nitrosyl-hemoglobin (HbNO) ( 2.1.1 NO enhances erythrocyte deformability Erythrocyte deformability, the capacity of red blood cells to alter shape as they traverse narrow capillaries, is vital for effective oxygen delivery