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Treatment Options for Glioblastoma There is some debate on whether autophagy inhibition or induction could be exploited as a novel anti-cancer approach, and how autophagy-targeting drugs could be applied in the standard radio-chemotherapeutic regimens in cancer patients, since some data show that autophagy inhibition increases the efficacy of radiation and chemotherapeutic agents, increasing the cytotoxicity of various treatments [198,199,200]

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3.17) share the “nested and discohesive” pattern, characterized by the presence of large, confluent nests at the dermal-epidermal junction, along with diminished melanocytic cohesion (88)