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Its distinctive role lies in deep gene‑expression regulation—it influences thousands of human genes, stimulates fibroblast production of collagen, elastin, and glycosaminoglycans, suppresses inflammation via JAK1 pathway downregulation, reduces reactive oxygen species, and delivers copper ions directly to damaged sites to facilitate tissue remodelling
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These studies highlight the potential of pH-responsive nanoplatforms in enhancing therapeutic outcomes through precise drug delivery and efficacy modulation in acidic disease microenvironments
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