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However, aspirin can also trigger episodes in many patients Montelukast (Singulair) and zafirlukast (Accolate) to block the effects of leukotriene C4 (LTC4) and zileuton (Zyflo) to block LTC4 production While these medications can be very helpful for dialing down the immune response and alleviating symptoms, we are committed to helping our patients identify and address the root cause of mast cell activation syndrome