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One of the main identified targets is the nitric oxide (NO) pathway, where the peptide acts as a modulator of NO synthesis via NO synthase (NOS) enzymes
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Research using IGF-1 LR3 centres on the IGF-1 receptor (IGF-1R) tyrosine kinase and its downstream PI3K/Akt and Ras/MAPK cascades, which drive cell proliferation, differentiation and protein synthesis
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