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D ss Continuous Rate Infusions with Bolus Dosing As seen, above starting an infusion at the rate required to maintain steady state is inefficient: For any desired plasma concentration, it will take three time constants (4-5 half-lives) for a continuous infusion to reach this concentration If the half-life is long, then achieving a therapeutic level will take some time A bolus dose aimed to fill the V D will allow steady-state to be reached immediately: Stopping an Infusion For a bi-exponential model (i.e

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Structural basis behind the interaction of Zn 2+ with the protein α-synuclein and the Aβ peptide: a comparative analysis