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[ 30 ] Heme triggers BACH1 degradation through the ubiquitin‐proteasome pathway by promoting its interaction with the ubiquitin E3 ligase adaptor proteins F‐box protein 22 (FBXO22, a cullin‐RING ligase 1 (CRL1) substrate receptor), and the activated NRF2 induces HO‐1 expression, thus represses the FBXO22‐dependent degradation of BACH1 in lung cancer cells
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