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Ethacrynic acid is both a substrate and a potent inhibitor (H-site binder) of GSTP, GSTA, and GSTM enzymes, with the most potent inhibition activity of GSTP1-1 [233] due to the α,β-unsaturated carbonyl group, which is capable of covalently binding to cysteine residues in the active site of the enzyme [234]
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