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In the central nervous system, HGF/c-Met signaling participates in: Synaptogenesis — the formation and maturation of dendritic spines and new synaptic connections Neuronal survival — activation of antiapoptotic pathways (PI3K/Akt, MAPK) Angiogenesis and tissue regeneration — repair processes following injury Synaptic plasticity — modulation of processes underlying learning The hypothesis of the Harding group linked these two systems: Dihexa, as a modified derivative of Ang-IV, would act not so much through IRAP itself as through strengthening (augmentation) of HGF/c-Met signaling — increasing the system’s sensitivity to endogenous HGF and intensifying synaptogenesis

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Real Coding Examples Example 1: Additional Hour Qualifies Infusion: Rocephin Start: 1000 Stop: 1145 Total time: 1 hour 45 minutes Coding: CPT 96365 CPT 96366 The infusion exceeded the midpoint of the second hour, allowing one additional hour to be reported