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Risk of renal injury In addition to CVD and GI complications, NSAIDs also carry a significant risk of kidney damage [171] which includes multiple nephrological complications like acute kidney injury (AKI), and chronic kidney disease (CKD) encompassing electrolyte imbalance, glomerulonephritis, renal papillary necrosis, fluid retention-induced hypertension, renal tubular acidosis, hyponatremia and hyperkalemia to name a few [172], [173]
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