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Prolonged supplementation (≥5 days) was associated with a reduction in new infections, suggesting that timing and duration may influence outcomes

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Only PLD2-activating and MOR-internalizing agonists such as DAMGO, β -endorphin, methadone, piritramide, fentanyl, sufentanil, or etonitazene were found to stimulate the MOR-mediated production of reactive oxygen molecules, primarily H 2 O 2 , via NADH/NADPH oxidase (Koch et al., 2009)