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Key Findings CagriSema demonstrated superior HbA1c reduction compared to semaglutide alone in patients with type 2 diabetes Greater body weight reduction with CagriSema versus individual components Adverse event profile consistent with GLP-1 and amylin class effects, predominantly gastrointestinal Supported advancement to phase 3 development for type 2 diabetes indication Limitations: Phase 2 study with limited durationRelatively small sample size for safety assessmentLong-term cardiovascular outcome data not available Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity D'Ascanio AM, Mullally JA, Frishman WH (2024) • Cardiology in Review Comprehensive review of amylin biology and the development of amylin analogs including cagrilintide for the treatment of obesity and type 2 diabetes