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Several authors confirmed the high frequency of hyperlactacidemia and increased lactate/pyruvate ratio as well as elevated alanine levels in blood and serum of ASD patients [Figure 8].[240] Several researchers have reported evidence of mitochondrial dysfunction in ASD brain samples compared to controls.[9,45,94,250] If such dysfunction is present at the time of infections and immunizations in young children, the added oxidative stress from immune activation on cellular energy metabolism is likely to be especially critical for the CNS, which is highly dependent on mitochondrial function

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To further validate the activating effect of neutrophils on monocytes, neutrophils from the bone marrow of naïve mice were adoptively transferred prior to CTT to amplify the neutrophil response ( Figure 2G )