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Limitations of metabolite-centric models in explaining rapid exercise responses Gut microbial metabolites like short-chain fatty acids (SCFAs), secondary bile acids, and tryptophan-derived compounds, drive chronic exercise adaptations (improved insulin sensitivity, enhanced lipid oxidation and skeletal muscle mitochondrial function) via systemic signaling over hours to days 18,19,20,21,22,23
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doi: 10.1016/j.bbcan.2024.189256 24 JoelE-RAlbertSWSDouglasEBElaineYLVictoriaO-VToriRet al
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