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Previously discussed, Gaucher’s Disease results from a dysfunctional autophagy-lysosome system, which is key in degrading misfolded proteins that contribute to nontypical and improper protein accumulation common in late onset neurodegenerative diseases (McNeill et al., 2014)
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For instance, studies have identified that tumors exhibiting high TYRO3 gene expression manifest resistance to PD-1/PD-L1 blockade by impeding ferroptosis, resulting in resistance in syngeneic mouse models and patients receiving anti-PD-1/PD-L1 therapy [7,8]
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