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These complexes generate ROS, depolarize mitochondria, and activate ER stress-associated genes (e.g., p21/GADD45A), but without prominently engaging canonical UPR branches such as PERK, IRE1, or ATF6
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HIV-associated neurocognitive disorders (HAND) share overlapping features with PD, including bradykinesia and cognitive dysfunction (Denaro et al., 2022
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