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Results GLUT1 overexpression enhances glycolysis and oxidative phosphorylation We first investigated CAR-T cell dependency on glucose by monitoring the effects of glucose deprivation on expansion of the clinically relevant CD19.28ζ-CAR as well as the high-affinity GD2 targeting HA.28ζ-CAR, which undergoes antigen-independent tonic signaling and manifests hallmark features of T cell exhaustion within 10 days of in vitro culture 24,25,26
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Moreover, ultrastructural alterations in hepatocytes, including mitochondria, rough endoplasmic reticulum, and cell nuclei, were noted
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