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Comprehensive SOPs and traceability management throughout the production chain can reduce source-level variability ( Optimizing in vivo exposure profiles of HDAC modulators is constrained by low oral bioavailability, largely due to poor water solubility, limited intestinal mucosal permeability, and degradation from gut microbiota metabolism and hepatic first-pass effects
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10.1038/s41467-022-28743-5
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