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Furthermore, regarding the clinically prevalent issue of bovine mastitis, the core volatile oil component of HC, 2-methylnonyl ketone (MNK), protected bovine mammary epithelial cells from LPS-induced oxidative damage and inflammatory injury by inhibiting the TLR4-NF-κB signaling pathway and activating the Nrf2/HO-1 pathway (41)
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Also, in contrast with previous reports, R-β-hydroxybutyrate, while inducing histone β-hydroxybutyrylation, did not display a readily detectable HDAC inhibitor activity and exerted a slight pro-inflammatory action on endothelial cells
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