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Cagrilintide for Research Use Only | Astramide
While commenters expressed support for further exploration of gaps related to pain, they also described confusion based on the prior CMS decision to remove this domain as a performance measure in home health due to the opioid crisis, and the need for CMS to send a consistent message to providers if new measurements were developed
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From a clinical perspective, emphysema-dominant patients may be more likely to exhibit mitochondrial damage and ferroptosis susceptibility features, chronic bronchitis or frequent exacerbation patients may lean toward an inflammasome/pyroptosis active state, and those with significant exercise intolerance, sarcopenia, or metabolic abnormalities may be closer to the extrapulmonary mitochondrial failure phenotype (136)
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