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NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity
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They reported a cytochrome P450-mediated formation of a reactive metabolite, now identified as N-acetyl-p-benzoquinone imine (NAPQI) [9] , which can be detoxified by glutathione (GSH) [7,8]
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