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[9] No overdosage or toxicity has been recorded by the FDA

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The biological profile of lipolytic growth hormone fragments observed in preclinical models includes: Lipolysis stimulation — stimulation of the breakdown of triglycerides in adipocytes, imitating the lipolytic C-terminal region of hGH Inhibition of lipogenesis — limiting the synthesis and deposition of new fat in adipose tissue No growth activity — unlike full hGH, the fragment does not significantly stimulate IGF-1 synthesis or cell growth Neutral glucose profile — no diabetogenic effect typical of full growth hormone in preclinical models Fat-loss specific profile — selective activity at the level of lipid metabolism without a multiaxial full hormone profile HGH Fragment 176-191 occupies the position of the native lipolytic core in this group – the unmodified reference point against which stabilized derivative variants such as AOD-9604 are compared