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The regulation of its activity is mainly dependent on the ubiquitin-mediated protein degradation pathway
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HRASV12-induced replication stress depends on the replisome-associated ROS sensor PRDX2 and is linked to PRDX2-dependent dissociation of TIMELESS from the replisome R-loop-mediated replication fork stalling caused by excessive ROS levels depends on the replisome-associated ROS sensor PRDX2 14
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