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3.4.4 Interactive crosstalk between T Cells, airway epithelial cells, eosinophils, and airway smooth muscle cells Airway hyperresponsiveness is a major pathological manifestation of asthma characterized by bronchoconstriction resulting from interactions among T cells, airway epithelial cells, eosinophils, and ASMC ( IL-13/IL-17 signaling: IL-13 and IL-17, inflammatory mediators from Th2 and Th17, respectively, increase the expression of GTPase RhoA protein in ASMC (93)
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