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Weibull distribution modeling characterized failure patterns of time-to-onset data, where the shape parameter (β) defined three scenarios: the upper limit of 95% confidence interval (CI) of β 1 (wear-out failure: risk escalation with prolonged use) 22 (Table S4)

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Interestingly, although not fully elaborated on, the authors also demonstrated binding sites for HIF1α, STAT3, and NF-κB in Shha , suggesting that this kinase may additionally act on these factors to regulate redox balance during wound healing 130