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Such a mechanism may also clarify how CCS promotes and/or facilitates high‐affinity zinc binding to apo‐SOD1 in human cells (Figure 3),[ 43a , 43b , 52 ] whereby structural changes in CCS D3 are proposed to stabilise the metal‐binding loop of SOD1 protein to generate a complete SOD1 Zn‐binding site ready for Zn 2+ incorporation
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