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B12 Headache: The Link Between Vitamin B12 and Headaches
In the context of EDC, elevated LPS levels caused by gut microbiota dysbiosis can be considered a “third hit.” Building upon existing central pathologies, this “third hit” exacerbates neuroinflammation, synergistically worsening both epileptic seizures and depressive symptoms, thereby perpetuating a vicious cycle (Arora et al., 2022)
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In contrast, the COPD group exhibited a pro-inflammatory and pro-oxidative profile, characterized by elevated BALF immune cell infiltration and increased MDA levels
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