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In in vitro studies, the nanoparticles were efficiently internalized, escape lysosomes, target mitochondria, scavenge ROS, reduce mitochondrial stress, restore membrane potential, increase ATP, and regulate apoptotic proteins (Bax↓, C-caspase 3↓, Bcl-2↑)
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Specific multi-strain formulations also exhibit promise in both preventing the initial onset of pouchitis and in maintaining remission following its successful induction
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