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It has been estimated that the body uses these cues to synchronize the oscillatory expression of up to 10% of genes, which thereby regulate many different physiological and biochemical processes (146)

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A study has postulated that muscle injury in an older person combined with immune aging would cause secondary damage to healthy muscle from aberrantly migrating neutrophils, resulting in myocyte damage and apoptosis and loss of muscle fibers, which could result in functional loss and physical weakness associated with frailty (175)

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