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Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver - ScienceDirect

Aging and the Free Radical Theory support some observations: (1) increasing levels of ROS formation and oxidative stress with aging (2) a steady increase in mitochondrial dysfunction with aging (3) an increase in ROS generation following inhibition of electron transport chain components (4) a decrease in peroxisomal function with aging According to available data, cellular senescence of mesenchymal stem cells (MSC) occurs with aging due to excessive ROS produced by complex I functional deficiency combined with depressed Ndufs6.58 Overproduction of ROS with aging limits bone formation and promotes bone breakdown by disrupting the balance of oxidative and antioxidant defense mechanisms.59 ROLE OF ANTIOXIDANTS IN THE REDUCTION OF ROS Antioxidants play a crucial role in reducing reactive oxygen species (ROS) by directly neutralizing them through electron donation, effectively acting as “scavengers” that prevent oxidative damage to cellular components like proteins, DNA, and lipids, thus mitigating oxidative stress and protecting against various diseases associated with excessive ROS production

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Pek Berbilang:Pek 12

DOI: 10.6133/apjcn.2016.25.1.23 3