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After the reaction was completed, the reaction mixture was concentrated in vacuo at 30-35 o C to reduce the 2/3 solvent amount, and then added dropwise into a stirring TBME (30.0 mL) to get precipitate
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The mecillinam/avibactam combination therapy may be a new, effective antibiotic treatment for MDR Gram-negative pathogens that produce carbapenemase (List et al., 2022)
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