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CBS has also been reported to be a substrate for sumoylation by the E3 SUMO ligase, human polycomb group protein 2, which decreases its activity (Agrawal and Banerjee, 2008)
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Their synthesis is regulated by multiple factors, including the availability of ribose-5-phosphate, the content of reaction products, and the concentration of 2,3-BPG, which accumulation leads to monomerization of the PRPP synthase enzyme resulting in loss of enzyme activity [5]
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