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IL-17A and IL-6 caused an increase in both MUC5B and MUC5AC gene expression in primary tracheal epithelial cells (Chen et al., 2003), and IL-17A caused an increase of MUC5AC in primary human bronchial epithelial cells through the NF-κB enhancer of MUC5AC gene transcription (Fujisawa et al., 2011

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When administered by intravenous (IV) injections, the QMP-engineered albumin variant lacking L585 demonstrated enhanced cellular recycling and extended plasma half-life in transgenic mice expressing human FcRn, comparable to that of full-length QMP