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At optimal concentrations, GHK-Cu increases mRNA production for collagen types I and III, elastin, proteoglycans, and glycosaminoglycans, while laboratory studies show that topical application for 12 weeks improves collagen production in 70% of subjects compared to 50% with vitamin C and 40% with retinoic acid

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In addition, administration of the drug in a thrombotic mouse model revealed a significant decrease in the area of cerebral edema, the area of cerebral infarction, and the expression of pro-inflammatory factors in mice (Keuters et al., 2021)