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Important NHS prescribing conditions include: Treatment must be initiated and supervised by a specialist weight management service Treatment should only continue if at least 5% of total body weight is lost after 12 weeks at the maintenance dose For semaglutide (Wegovy), treatment should not continue for longer than 2 years Documented evidence of previous weight loss attempts through diet and exercise Engagement with a structured weight management programme Commitment to ongoing lifestyle modifications Women with PCOS who have developed type 2 diabetes may be eligible for GLP-1 medications through diabetes treatment pathways, which have separate prescribing criteria

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A review of these peptides describes their role in energy metabolism and how they help cells respond to metabolic stress (a review of mitochondrial derived peptides and their role in energy metabolism, published in American Journal of Physiology