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Concurrent administration of the two peptides is thus believed to have more potent healing effects, with research suggesting a synergistic effect to accelerate the migration of fibroblasts and immune system cells to sites of injury [8, 9, 11]

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Excessive reactive oxygen species accumulation and antioxidant enzyme inhibition (particularly superoxide dismutase) can activate crucial signaling cascades including NF-κB and MAPK, subsequently promoting pro-inflammatory mediator synthesis and release (Tarek et al., 2023