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Riboflavin | Linus Pauling Institute | Oregon State University
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For example, ORF3a forms ion channels at the outer mitochondrial membrane to disturb calcium balance and trigger apoptosis, ORF5 downregulates MAVS-related signaling by limiting TBK1/IRF3 recruitment, while ORF6 alters the mitochondrial proteome while suppressing MAVS signaling [91,92]
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