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Mutations in the genes encoding these proteins, as well as their abnormal expression, are associated with the pathogenesis of several diseases, including type 2 diabetes, insulin resistance, cancer, and neurodegenerative disorders
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They also regulate the Treg/Th17 balance via the mechanistic target of rapamycin (mTOR)–hypoxia-inducible factor α (HIF-1α) or IL-6–STAT3–HIF-1α signaling pathways (Shi et al., 2017
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