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The escalation in ROS/RNS may be precipitated by NMDA receptor signaling in postsynaptic neurons, which leads to the desensitization of NMDA receptors through nitration and nitrosylation, thereby conferring protection against Glu-induced excitotoxicity
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Importantly, overfed rats in this model maintain the obese phenotype and the associated metabolic disturbances throughout their lifespan 115–118
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