glutathione glutamate release Extracellular levels of glutamate, glutamine, cystine, glutathione, and xanthine correlate with transporter expression in tamoxifen - resistant MCF-7 cells and poor overall survival in breast cancer patients 9176

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Of interest also are the recent findings that NAC impacts neurotransmission not only through its antioxidant activities, but also through elevation of extracellular glutamate levels via the cystine/glutamate antiporter and subsequent actions on both N -methyl-d-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors [46,47,53]