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Published human data consists of fewer than 30 subjects across three uncontrolled pilot studies: a retrospective knee injection review (12 patients, 11 reporting subjective pain relief), an interstitial cystitis pilot (12 patients), and a two-person IV safety study
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302 ECM-degrading enzymes regulate VEGF signaling through: releasing bio-unavailable ligands: due to the varying heparin-binding and heparan sulfate-binding capacities of VEGF isoforms, some VEGF ligands are sequestered in the ECM
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