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several lines of investigation have suggested various putative models for ATP release from astrocytes (Koizumi, Connexin 43 (Cx43) assembles into a hemichannel which constitutes gap junctions in astrocytes, and exchanges signaling molecules, including Ca 2+ and inositol 1,4,5-trisphosphate, between adjacent astrocytes (Orellana and Stehberg, 2+ ] i increase and ATP release in astrocytes of hippocampal slices, which were inhibited by application of a hemichannel blocker and in Cx43/Cx30 knockout mice (Torres et al., 2012), suggesting that ATP is released extracellularly through Cx43 hemichannels
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