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on the other hand, under hypoxic conditions, HIF-α subunits interact with prolyl hydroxylases (PHDs), alleviating PHD-driven inhibition of IKKβ and partially activating the canonical NF-κB pathway (Scortegagna et al., 2008), and the abnormal upregulation of inflammatory molecules and cytokines further promotes lung cancer cell proliferation, invasion, and metastasis (Tang et al., 2025
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Psychiatry 25 , 1787–1808 (2020)
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