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More elegantly, the peptide itself can be redesigned for stability — unnatural amino acids (like Aib), cyclization, D-amino acid substitutions, and PEGylation all make the molecule harder for proteases to cleave and can extend half-life

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This approach is unaffected by confounding factors and reverse causal associations, which are the reverse chronological order of exposure and outcome found in traditional epidemiological studies ( In this study, we performed a two-sample bidirectional MR using publicly available genome-wide association study (GWAS) summary statistics to explore the causal relationship between VEGF and the risk of multiple cancers, including breast cancer, ovarian cancer, lung cancer, colorectal carcinoma, prostate cancer, esophageal cancer, kidney cancer, bladder cancer, brain malignant tumors, and malignant tumors of the liver and intrahepatic bile duct