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To maintain the cyclic structure of the LyP-1 peptide as well as the CendR motif, DOTA was conjugated with the -NH 2 of the cysteine at the N-terminus of LyP-1 either directly or via the 6-aminocaproic acid (ACP) spacer (Fig
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It went from Monash laboratory to human clinical trials, cleared early phases, stumbled at the Phase IIb finish line for weight loss, then found unexpected staying power through a safety designation and emerging cartilage research that nobody originally planned for
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