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It is important to note that this concern is entirely theoretical -- no oncological adverse effects have been reported in the limited preclinical studies -- but the biological plausibility is high enough to warrant serious consideration

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In the latest clinical trial, OS and progression-free survival (PFS) in months was calculated for Phase 2 of Tepotinib 500 mg (5.55 and 3.22 months, respectively) (NCT02115373)